FLUORINATED CATHARANTHINE DERIVATIVES, THEIR PREPARATION ANDTHEIR UTILISATION AS VINCA DIMERIC ALKALOID PRECURSORS

摘要

The fluorinated derivatives of catharanthine according to the invention r espond to the general formula (I) in which: the dotted line expresses the po ssibility of the presence of a double bond when the substitution -X is absen t or else a single bond when -X designates a substitution for a group: H, OR , NR' R", SR, or a halogen atom with R, R' and R" designating independently of one another a hydrogen atom or a linear or branched alkyl group in C1 to C6, R1, R2 and R3 represent independently of one another an atom of hydrogen , of fluorine or a methylated group, on the condition nevertheless that at l east one of the radicals R1 and R2 represents an atom of fluorine, and n = 1 or 2.