METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF
摘要
The present invention relates to a computer-assisted method of a designing of a PARP inhibitor comprising: a) determining an interaction between a candidate PARP protein and a known PARP inhibitor by evaluating a binding of the PARP protein to the known PARP inhibitor; b) based on the interaction, designing a candidate PARP inhibitor; c) determining an interaction between the PARP protein and the candidate PARP inhibitor by evaluating a binding of the PARP protein to the candidate PARP inhibitor; and d) concluding that the candidate PARP inhibitor inhibits the PARP protein wherein the conclusion is based on the interaction of step c). The invention also provides methods for treatment of diseases with the candidate PARP inhibitors.
申请公布号
WO2008030887(A2)
申请公布日期
2008.03.13
申请号
WO2007US77655
申请日期
2007.09.05
申请人
BIPAR SCIENCES, INC.;OSSOVSKAYA, VALERIA;BURNIER, JOHN;SHERMAN, BARRY;TOTROV, MAX
发明人
OSSOVSKAYA, VALERIA;BURNIER, JOHN;SHERMAN, BARRY;TOTROV, MAX