USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN

摘要

Polyols stabilize polymorphous form of rifaximin, in particular the ß form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ß is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.