| 摘要 |
<p>The invention provides a composition comprising core-shell nanoparticles, the nanoparticles comprising (a) cationic core material comprising polymer; and (b) a shell material comprising silica. Preferred core materials compri se diblock copolymer micelles comprising one block of dialkylaminoethyl meth acrylate units which are partially or fully quaternised and one block of dia lkylaminoethyl methacrylate units that remain non- quaternised. The inventio n also provides a method for the preparation of the said composition, the me thod involving (a) preparing a cationic core material comprising polymer; an d (b) coating the core material with a shell comprising silica by treating t he polymer with a silica precursor under ambient conditions. The invention a lso envisages a composition comprising core-shell nanoparticles which is ada pted to facilitate controlled delivery of at least one active agent into a s ystem in response to controlled changes in the pH of the system.</p> |
