METHOD OF PRODUCING POTASSIUM [18F] FLUORIDE AND QUATERNARY AMMONIUM [18F] FLUORIDE AND METHOD OF PRODUCING RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND BY USING THE SAME

摘要

PROBLEM TO BE SOLVED: To prevent the formation of impurities caused by the decomposition of a substrate in the process of producing a radioactive fluorine-labeled compound. SOLUTION: The method of producing potassium [18F] fluoride or quaternary ammonium [18F] fluoride contains a process for removing cationic impurities by bringing18O-concentrated water containing [18F] fluoride ion into contact with a strongly acidic cation exchange resin, a process of bringing the18O-concentrated water into contact with a weakly basic anion exchange resin where the weakly basic anion exchange resin adsorbs the [18F] fluoride ion, and a process for eluting the [18F] fluoride ion adsorbed by the weakly basic anion exchange resin by using an aqueous solution of a potassium salt (excluding potassium carbonate and potassium hydrogencarbonate) or a solution of a quaternary ammonium salt (excluding hydrogencarbonate). The method of producing a radioactive fluorine-labeled organic compound contains a process for labeling an organic compound by using the potassium [18F] fluoride or the quaternary ammonium [18F] fluoride obtained by the production method. COPYRIGHT: (C)2008,JPO&INPIT