| 摘要 |
The invention relates to a method for identifying and selecting a compound acting as an allosteric regulator of a GPCR-III. According to said method, the activity level of a recombinant GPCR-III (GPCR-III-?), essentially depleted of the extracellular domain of the corresponding native GPCR-III in the presence of a given compound, is compared to the activity level of the same GPCR-III? in the absence of said compound, enabling positive or negative allosteric regulators of GPCRs-III to be identified and selected. The invention also relates to the application of one such method for identifying and selecting compounds of interest in fields of activity such as pharmacy, the agro-food industry, the environment, ecology and basic research.
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