| 摘要 |
A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R<SUP>1 </SUP>is H or halogen; R<SUP>2 </SUP>is Ar, Ar-C(O)-, Ar-CH<SUB>2</SUB>-, Ar-SO<SUB>2</SUB>-, Ar-O-C(O), or R''-C(O)-, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R' and R'' independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R<SUP>3 </SUP>is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.
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