Solid drug for oral use comprising indoline compound

摘要

Disclosed is a tablet which comprises: (1) a granular material containing a) as an active ingredient, a compound represent by the formula 1, b) D-mannitol, c) low substituted hydroxylpropylcellulose, and d) hydroxypropylcellulose, and (2) a lubricant selected from magnesium stearate, calcium stearate or talc, Wherein 85% dissolution time is note more than 60 minutes in a dissolution test according to method 2 (paddle method) of Japanese pharmacopoeia in a condition using water as a test medium and a paddle speed of 50 rpm.