| 摘要 |
FIELD: organic chemistry, medicine, gynecology. ^ SUBSTANCE: invention relates to using compound of the formula (I): or its isomers, pharmaceutically acceptable salt, or its metabolite of the following group: TORE VI [4-hydroxy-(deaminohydroxy)-toremifene], TORE VII [(4,4'-dihydroxy-(deaminohydroxy)-toremifene, TORE XVIII [(deaminocarboxy)-toremifene, TORE VIII [4-hydroxy-(deaminocarboxy)-toremifene, TORE XIII (toremifene monophenol) for preparing a pharmaceutical composition used in inhibition of urogenital atrophy in women, or in treatment or prophylaxis of symptoms associated with this pathology. Invention provides the improved inhibition of this atrophy and relief of its symptoms based on the enhanced pattern of estrogenic and anti-estrogenic effect of used compounds as compared with the known SERM. ^ EFFECT: improved, enhanced and valuable medicinal properties of method. ^ 5 cl, 4 dwg, 1 tbl |
