STABILIZED FORMULATION OF SELECTIVE LIGANDS OF RETINOIC ACID GAMMA-RECEPTORS

摘要

The present invention relates to a method of administering a compound of Formula I:whereinR<1 >is hydrogen or C1-6-alkyl;R<2 >is C1-6-alkyl or adamantyl;R<3 >is C1-6-alkyl or hydroxy; orR<2 >and R<3 >taken together are -(CR<6>R<7>)n-;R<4 >is C2-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, -OCH2R<5 >or C2-8-alkanoyl, or hydrogen when R<3 >is hydroxy;R<5 >is C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl;R<6 >and R<7 >are hydrogen or C1-6-alkyl;Y is oxygen or sulfur; andn is 3, 4, or 5,or a pharmaceutically acceptable salts of carboxylic acid of formula I,wherein said method comprises the step of admixing said compound in solid form with a topical carrier to form a topical formulation within seven days prior to first topical administration of said compound.