| 发明名称 |
METHOD FOR INHIVITION OF PHOSPHOLAMBAN ACTIVITY FOR TREATMENT OF CARDIAC DISEASE AND HEART FAILURE |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel method for the treatment of heart failure. <P>SOLUTION: A method for the treatment of heart failure is provided through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing heart and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban with sarcoplasmic reticulum Ca<SP>2+</SP>ATP-ase (SERCA2a) within cardiomyocytes. In addition, a means is provided for transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes. <P>COPYRIGHT: (C)2008,JPO&INPIT |
| 申请公布号 |
JP2008037870(A) |
申请公布日期 |
2008.02.21 |
| 申请号 |
JP20070204986 |
申请日期 |
2007.08.07 |
| 申请人 |
REGENTS OF THE UNIV OF CALIFORNIA |
发明人 |
CHEN KENNETH;DILLMAN WOLFGANG;MINAMISAWA SUSANNE;HE HUAPING;HOSHIJIMA MASAHIKO;MEYER MARKUS;SCOTT CHRISTOPHER;WANG YIBIN;SILVERMAN GREGG J |
| 分类号 |
A61K48/00;C12N15/09;A61K35/76;A61K38/00;A61K38/17;A61K39/395;A61P9/04;A61P43/00;C07K14/47 |
主分类号 |
A61K48/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
