摘要 |
Compounds of general formula I: wherein: R<SUB>1 </SUB>and R<SUB>2 </SUB>are, independently of each other, selected from hydrogen, optionally substituted C<SUB>1-10</SUB>alkyl, optionally substituted -CO-(C<SUB>1-10</SUB>alkyl), optionally substituted C<SUB>3-10</SUB>cycloalkyl, optionally substituted -CO-(C<SUB>3-10</SUB>cycloalkyl), optionally substituted C<SUB>2-10</SUB>alkenyl, optionally substituted -CO-(C<SUB>2-10</SUB>alkenyl), optionally substituted aryl, and optionally substituted -CO-aryl, or R<SUB>1 </SUB>and R<SUB>2 </SUB>together represent an optionally substituted saturated or unsaturated C<SUB>1-10</SUB>alkylidene group, or an optionally substituted saturated or unsaturated C<SUB>3-10</SUB>cycloalkylidene group, or R<SUB>1 </SUB>and R<SUB>2 </SUB>together with the carbon atom to which they are attached represent an optionally substituted saturated or unsaturated organic ring containing 3, 4, 5, 6, 7 or 8 ring carbon atoms and optionally 1, 2 or 3 ring heteroatoms selected from O, N and S; R<SUB>3</SUB>, which may be the same as, or different from, either of R<SUB>1 </SUB>and R<SUB>2</SUB>, is selected from optionally substituted C<SUB>1-10</SUB>alkyl, optionally substituted C<SUB>3-10</SUB>cycloalkyl, optionally substituted C<SUB>2-10</SUB>alkenyl, and optionally substituted aryl; R<SUB>4</SUB>, R<SUB>5 </SUB>and R<SUB>6 </SUB>are, independently of each other, selected from hydrogen, optionally substituted C<SUB>1-10</SUB>alkyl, OH, optionally substituted C<SUB>1-10 </SUB>alkoxy, halo, optionally substituted aryloxy, optionally substituted (C<SUB>1-10</SUB>alkyl)-S(O)<SUB>n</SUB>- where n=0, 1 or 2, optionally substituted aryl-S(O)<SUB>n</SUB>- where n=0, 1 or 2, or R<SUB>4 </SUB>is hydrogen and R<SUB>5 </SUB>and R<SUB>6 </SUB>together represent an optionally substituted saturated or unsaturated organic chain containing 1, 2, 3, 4, 5, 6 or 7 chain carbon atoms and optionally 1, 2 or 3 chain heteroatoms selected from O, N and S, provided that the chain is at least 3 atoms long; with the proviso that, when R<SUB>1</SUB>-R<SUB>2</SUB>=hydrogen, then any optionally substituted C<SUB>1-10</SUB>alkyl or optionally substituted C<SUB>2-10</SUB>alkenyl for R<SUB>3 </SUB>must have a branch point at one or more of the alpha and beta positions counted from the carbonyl group (or tautomeric form thereof) to which R<SUB>3 </SUB>is attached; or a physiologically acceptable salt, complex or prodrug thereof; are disclosed per se and for use in the treatment or prophylaxis of hypersensitivity, smooth muscle disorders, spasmodic conditions, allergic conditions, inflammatory conditions and/or pain.
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