Process of preparation of benzimidazol-2-yl quinolinone derivatives
摘要
<p>The present invention relates to methods for synthesizing a 4-amino substituted compound of structure I, where the variables have the values described herein. The methods comprise reacting a substituted or unsubstituted ethyl 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile and a base or a Lewis acid, whereby the 4-amino substituted compound of structure I is provided.</p>
申请公布号
EP1650203(B1)
申请公布日期
2008.02.20
申请号
EP20050017665
申请日期
2001.09.11
申请人
NOVARTIS VACCINES AND DIAGNOSTICS, INC.
发明人
RENHOWE, PAUL;PECCHI, SABRINA;MACHAJEWSKI, TIM;SHAFER, CYNTHIA;TAYLOR, CLARKE;MCCREA, BILL;MCBRIDE, CHRIS;JAZAN, ELISA;WERNETTE-HARMMOND, MARY-ELLEN;HARRIS, ALEX L.