BIOMARKERS FOR INFLAMMATION OF THE LIVER

摘要

The invention relates to a method for the diagnostic investigation of bio logical samples from a person for inflammation of the liver, in particular h epatic fibrosis and/or cirrhosis of the liver, where the sample is investiga ted for one or more proteins as markers of inflammation of the liver, in par ticular hepatic fibrosis and/or cirrhosis of the liver, where a concentratio n of the proteins which is elevated or decreased by comparison with the heal thy state indicates the presence of an inflammation of the liver, in particu lar a hepatic fibrosis and/or cirrhosis of the liver. The proteins are selec ted from the group of ER6Q, vimentin, actin alpha 1 skeletal muscle protein, hMFAP 4, tropomyosin, PTGES 2, amyloid P component, transgelin, calponin 1, homo sapiens p20 protein, 17 kDa myosin light chain, H chain H Igg B12, pro lyl 4-hydroxylase, beta subunit methylenetetrahydrofolate dehydrogenase 1, P RO2619, aldehyde dehydrogenase 1, fibrinogen alpha chain preproprotein, fruc tose-bisphosphate aldolase B, argininosuccinate synthetase, Eefla2, AT P 5 A l, alpha-2 actin, regucalcin, serum albumin, mitochondrial malate dehydrogen ase, mitochondrial acetoacetyl-CoA thiolase or in each case a partial sequen ce thereof.