| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing 3-chloro-7-nitroindole (II) and N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzene sulfonamide (VI) in good efficiency. SOLUTION: The method for producing N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide (VI) having a high purity comprises chlorinating 7-nitroindole with N-chlorosuccinimide in a hydrous solvent to produce 3-chloro-7-nitroindole (II) and reducing the compound (II) to obtain 3-chloro-7-aminoindole or its hydrochloride and reacting the 3-chloro-7-aminoindole or its hydrochloride in the presence of a base with 4-sulfamoylbenzenesulfonyl chloride synthesized from 4-aminobenzenesulfonamide. COPYRIGHT: (C)2008,JPO&INPIT
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