USE OF TPP II INHIBITORS IN COMBINATION WITH GAMMA-IRRADIATION FOR THE TREATMENT OF CANCER

摘要

TPP II (tripeptidyl peptidase II) inhibitors are useful in enhancing the efficacy of gamma- irradiation cancer therapy or increasing the in vivo gamma-irradiation susceptibility of tumour cells. Suitable compounds comprise tripeptide compounds of general formula R^N1R^N2N-A¹-A²-A³-CO-R^C1 wherein R^N1, R^N2, A¹, A², A³ and R^C1 are as defined herein, and which include for example the tripeptide sequences GLA and GPG. Complete in vivo tumor regression in mice injected with TPPII inhibitors is observed, during treatment in combination with gamma-irradiation.