PHARMACEUTICAL COMPOSITION, HEALTH FOOD COMPOSITION AND FARNESOID X-ACTIVATED RECEPTOR INHIBITORS, CONTAINING SCALARANE-BASED SESTERTERPENES

摘要

A pharmaceutical composition comprising scalarane-based sesterterpenes is provided to lower cholesterol level in the liver by inhibiting the activity of farnesoid X-activated receptor, so that the pharmaceutical composition is useful for prevention and treatment of cholesterol metabolism disease and hyperlipemia. A composition for prevention and treatment of cholesterol metabolism disease and hyperlipemia comprises scalarane-based sesterterpenes represented by the formula(1), wherein R1 is hydrogen, hydroxyl or acetoxy; R2 to R4 are each independently methyl, hydroxymethyl or acetoxymethyl; the scalarane-based sesterterpenes are isolated from Spongia sp.; the daily dosage of scalarane-based sesterterpenes is 0.001-400 mg/kg; and the composition is formulated as a pharmaceutical or a health food composition.