发明名称 |
ASYMMETRIC HYDROGENATION OF 1,1,1-TRIFLUOROACETONE |
摘要 |
<p>The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2- propanol by an asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex represented by formula Ru(E)(E')(L)(A) wherein E, E' are both chloro or E is hydrogen and E' is BH<SUB>4</SUB>; L is a chiral diphosphine ligand; and A is an optionally chiral diamine comprising the variants a) in the presence of a weak base and with or without an additive in case when E and E' are both chloro or b) in the absence of a base and an additive in case when E and E' are hydrogen and BH<SUB>4</SUB>.</p> |
申请公布号 |
WO2008012240(A1) |
申请公布日期 |
2008.01.31 |
申请号 |
WO2007EP57372 |
申请日期 |
2007.07.17 |
申请人 |
F. HOFFMANN-LA ROCHE AG;PUENTENER, KURT;WALDMEIER, PIUS |
发明人 |
PUENTENER, KURT;WALDMEIER, PIUS |
分类号 |
C07C29/145;C07C31/38 |
主分类号 |
C07C29/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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