COMPOSITIONS AND METH0DS FOR INHIBITING GASTRIC ACIDE SECRETION USING DERIVATIVES OF SMALL DICARBOXYLIC ACIDS IN COMBINATION WITH PPI

摘要

The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more aliphatic carboxylic acid derivativ e molecules which activate parietal cells, wherein the derivatives possess d elayed or sustained enhancement effect on the PPI activity compared to the n on-derivatized acid molecules. The present invention further relates to a me thod of using such compositions to reduce gastric acid secretion in a mammal .