发明名称 |
3'-ETHYNYLCYTIDINE DERIVATIVE |
摘要 |
<p>Disclosed is a compound which has excellent anti-tumor activity and excellent oral absorbability and is useful as an anti-tumor agent. Specifically disclosed is a 3'-ethynylcytidine derivative represented by the general formula (1) [wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by the formula: (R<SUP>1</SUP>)(R<SUP>2</SUP>)(R<SUP>3</SUP>)Si- and the other represents a group represented by the formula: (R<SUP>4</SUP>)(R<SUP>5</SUP>)(R<SUP>6</SUP>)Si-; and R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP> and R<SUP>6</SUP> independently represent a (substituted) alkyl group, a (substituted) cyclic alkyl group or a (substituted) aryl group] or a salt thereof.</p> |
申请公布号 |
WO2008012945(A1) |
申请公布日期 |
2008.01.31 |
申请号 |
WO2007JP00787 |
申请日期 |
2007.07.23 |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD.;SASAKI, TAKUMA;MATSUDA, AKIRA;TANAKA, MOTOAKI;FUKUSHIMA, MASAKAZU |
发明人 |
TANAKA, MOTOAKI;FUKUSHIMA, MASAKAZU |
分类号 |
C07H23/00;A61K31/7068;A61P35/00;A61P35/02;C07H19/06 |
主分类号 |
C07H23/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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