| 摘要 |
The present invention comprises a new class of compounds capable of modul ating the c-kit protein kinase and, accordingly, useful for treatment of c-k it mediated diseases including, without limitation, autoimmune disease, alle rgies, mastocytosis, mast cell related tumors and various fibrotic diseases. The compounds have a general Formula (I) wherein R1-5, X, Y and Z are defin ed herein. The invention further comprises pharmaceutical compositions, meth ods for treatment of c-kit mediated diseases, and intermediates and processe s useful for the preparation of compounds of the invention.
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