发明名称 |
COMPOSITIONS AND METHODS OF MAKING A PHOTOACTIVE AGENT |
摘要 |
An improved two stage reaction process for production of mono-L-aspartyl chlorin e<SUB>6</SUB>. In a first stage, the activation reaction between chlorin e<SUB>6 </SUB>and a carbodiimide produces a previously unknown anhydride in an activation reaction product. This reaction product is purified to remove a significant proportion of the precursors of di-L-aspartyl chlorin e<SUB>6</SUB>. The purified activation reaction product contains a higher concentration of the previously unknown anhydride. This purified reaction product is used in a second stage: a coupling reaction of the purified activation reaction product with aspartate. The coupling reaction produces a coupling reaction product that has significantly reduced di-L-aspartyl chlorin e6 concentration. This reduced di-L-aspartyl chlorin e6 concentration facilitates purification of mono-L-aspartyl chlorin e6 from the coupling reaction mixture.
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申请公布号 |
US2008021210(A1) |
申请公布日期 |
2008.01.24 |
申请号 |
US20070772024 |
申请日期 |
2007.06.29 |
申请人 |
LIGHT SCIENCES ONCOLOGY, INC. |
发明人 |
XU LEON;PALLENBERG ALEXANDER J. |
分类号 |
C07D491/22 |
主分类号 |
C07D491/22 |
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