ENHANCEMENT OF REGULATORY T CELLS' ACTIVITY USING STATINS

摘要

The present invention concerns a method of enhancing the numbers and activity of naturally occurring CD4+CD25+ regulatory T cells using statins, e.g. atorvastatin. Treatment with statins increases the number of Tregs in vivo and in vitro with concomitant upregulation of their master transcriptional activator foxp3. The invention further concerns a method of treatment of diseases which are characterized by an impaired function of Tregs.