发明名称 IMPROVED PROCESS FOR MANUFACTURING STATINS
摘要 <p>The present invention provides an improved process for manufacturing statins comprising the following steps (i) reacting lovastatin with butyl amine to produce lovastatin amide (ii) isolating lovastatin butylamide in solid form by crystallization, from organic solvent (iii) optionally subjecting to hydroxyl protection to get diprotected lovastatin butylamide, (iv) subjecting proteceted or unprotected amide so obtained to C-Methylation employing lithium pyrrolidide prepared in situ by reacting butyl lithium and pyrrolidine, isolating the title product by conventional methods, and converting to its pharmacologically acceptable salt by known methods.</p>
申请公布号 WO2007052309(A3) 申请公布日期 2008.01.17
申请号 WO2006IN00435 申请日期 2006.11.01
申请人 MOREPEN LABORATORIES LIMITED;SURI, SANJAY;KASHYAP, TAPAN;PUNDIR, GIRISH, CHANDRA;SINGH, NETAR 发明人 SURI, SANJAY;KASHYAP, TAPAN;PUNDIR, GIRISH, CHANDRA;SINGH, NETAR
分类号 C07D309/30;C07C69/74 主分类号 C07D309/30
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