DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED P2Y PURINORECEPTOR 7 (P2Y7)

摘要

The invention provides a human P2Y7 which is associated with the urological disorders, reproduction disorders, neurological diseases, respiratory diseases, hematological diseases, cancer, gastrointestinal and liver diseases, inflammation, endocrinological diseases and cardiovascular diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of urological disorders, reproduction disorders, neurological diseases, respiratory diseases, hematological diseases, cancer, gastrointestinal and liver diseases, inflammation, endocrinological diseases and cardiovascular diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of P2Y7 as well as pharmaceutical compositions comprising such compounds.