| 摘要 |
An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hlL- 18Ra), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID No: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID No: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof. |
| 申请人 |
REGENERON PHARMACEUTICALS, INC.;HUANG, TAMMY, T.;STEVENS, SEAN;MARTIN, JOEL, H.;FAIRHURST, JEANETTE, L.;POBURSKY, KEVIN, J.;KAROW, MARGARET;WINDSOR, JOAN, A.;MIKULKA, WARREN, R. |
发明人 |
HUANG, TAMMY, T.;STEVENS, SEAN;MARTIN, JOEL, H.;FAIRHURST, JEANETTE, L.;POBURSKY, KEVIN, J.;KAROW, MARGARET;WINDSOR, JOAN, A.;MIKULKA, WARREN, R. |
