ENZYMES CONJUGATED TO ANTIBODIES VIA A PEG HETEROBIFUCTIONAL LINKER
摘要
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
申请公布号
EP1877101(A2)
申请公布日期
2008.01.16
申请号
EP20060758689
申请日期
2006.04.27
申请人
VENTANA MEDICAL SYSTEMS, INC.
发明人
BIENIARZ, CHRISTOPHER;WONG, JENNIFER;LEFEVER, MARK;KOSMEDER, JEROME W.;ASHWORTH-SHARPE, JULIA;KERNAG, CASEY, A.