1,4-DI-SUBSTITUTED PIPERIDINE DERIVATIVES

摘要

This invention provides novel 1,4-di-substi- tuted piperidine derivatives of the general formula [I] <IMG> and the pharmaceutically acceptable salts thereof, wherein : Ar represents a phenyl group or a five- or six-membered heteroaromatic group having one or two hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom in which one or two optional hydrogen atoms on the ring may be replaced by substituent groups selected from the group consisting of a halogen atom and a lower alkyl group; R1 represents a cycloalkyl group of 3 to 6 carbon atoms or a cycloalkenyl group of 3 to 6 carbon a toms ; R2 represents a saturated or unsaturated aliphatic hydrocarbon radical of 5 to 15 carbon atoms; and X represents 0 or NH. These compounds have selective antagonistic activity against the muscarinic M3 receptors and can hence be used safely with a minimum of side effects. According- ly, they are useful in the treatment or prophylaxis of diseases of the respiratory system, such as asthma, chronic airway obstruction and fibroid lung; diseases of the urinary system accompanied by urination disorders such as pollakiuria, urinary urgency and urinary incon- tinence; and diseases of the digestive system, such as irritable colon and spasm or hyperanakinesis of the digestive tract.