摘要 |
FIELD: medicine, pharmaceutical technology, pharmacy. ^ SUBSTANCE: invention relates to injection moxifloxacin solution containing polysaccharide and accessory substance, and to a method for its preparing. The solution contains lactic or glycolic acid copolymer as accessory substance, and mannitol as polysaccharide in the following ratio of components, weight %: moxifloxacin, 2-3; lactic acid homopolymer or copolymer of lactic and glycolic acids, 23-26; mannitol, 4.0-5.5; polyvinyl alcohol, 0.8-1.3, and water, the balance, to 100%. The claimed method involves dissolving the therapeutically permitted amounts of moxifloxacin in water followed by addition of accessory substances solution. Lactic acid homopolymer solution or copolymer of lactic and glycolic acids in methylene chloride is used as accessory substances solution wherein moxifloxacin aqueous phase is added, and polyvinyl alcohol is added to the prepared emulsion to the concentration 0.8-1.3% and mannitol is added to the concentration 4.0-5.5%. The claimed composition and a method for its preparing provides preparing agent convenient in using and providing high therapeutic effectiveness and allow avoiding crystallization of active substance for prolonged time. ^ EFFECT: improved preparing method. ^ 3 cl, 2 tbl, 1 ex |