NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

摘要

Compounds are provided which are phosphonate and phosphinate activators a nd thus are useful in treating diabetes and related diseases and have the st ructure of Formula (I), wherein Formula (II) is a heteroaryl ring; R4 is -(C H2)n-Z-(CH2)m-PO(OR7)(OR8), -(CH2)nZ-(CH2)m-PO(OR7)R9, -(CH2)n-Z-(CH2)m-OPO( OR7)R9, -(CH2)nZ-(CH2)m-OPO(R9)(R10), or -(CH2)nZ-(CH2)m-PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or i s absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.