<p>The present invention relates to novel methods of designing and optimizing polypeptide based ligands which are useful for altering and/or modulating cellular signaling cascades which have become dysregulated. The therapeutic dominant negative ligands (DNLs) and DNL variants designed by the methods herein have useful applications in medicine, diagnostics and drug discovery.</p>
申请公布号
WO2008005992(A2)
申请公布日期
2008.01.10
申请号
WO2007US72762
申请日期
2007.07.03
申请人
MOLECULAR LOGIX, INC.;PIENKOS, PHILIP, T.;MONTICELLO, DANIEL, J.