A NOVEL ANTIMICROBIAL PEPTIDE PEP-1-K DESIGNED FROM THE CELL-PENETRATING PEPTIDE PEP-1 AND USES THEREOF

摘要

A novel synthetic or a recombinant antibacterial peptide is provided which shows strong antibacterial activity against various strains such as gram positive bacillus, gram negative bacillus and a strain having the resistance against antibiotics without any hemolytic activity in human erythrocyte cells, thereby being usefully used as a non-toxic antibacterial agent, a food preservative and a cosmetic additive. A synthetic or a recombinant antibacterial peptide is characterized in that it prepared by substituting at least one Glu at the 2nd, the 6th and the 11th of a cell-penetrating peptide Pep-1 with a positively charged basic amino acid such as arginine(Arg), histidine(His) and lysine(Lys) and it has the antibacterial activity against at least one strain selected from the group consisting of Bacillus subtilis KCTC 3068, Staphylococcus epidermidis KCTC 1917 and Staphylococcus aureus KCTC 1621. A non-toxic antibacterial agent comprises the antibacterial peptide as an effective ingredient.