| 摘要 |
#CMT# #/CMT# Cosmetic/dermatological composition (A) comprises a C-glycoside derivative (I) and a hydrating polymer (II). #CMT# : #/CMT# An independent claim is included for a non-therapeutic process of treatment or make-up of the keratinous matters, particularly skin, comprising applying a layer of the cosmetic composition (A) to the keratinous matters. #CMT#USE : #/CMT# (A) is useful as a cosmetic, dermatological or therapeutic active agent (claimed). #CMT#ADVANTAGE : #/CMT# (A) is non-invasive and non-destructive. (A) provides agreeable and comfortable sensation to the user. #CMT#ORGANIC CHEMISTRY : #/CMT# Preferred Components: (I) is of formula (S1-CH2-X-R), its salts, solvates such as hydrates and isomers. (I) is present in the composition at 0.0001-25 wt.%, preferably 0.05-5 wt.%. The liquid fatty phase is a volatile oil and/or nonvolatile oil, the solid fatty phase is gums and/or pasty greasy substances. X : -C(O)-, -CH(NR1R2)-, -CH(R1a)- or -C(=CHR3)-, preferably -CH(OH)-; R2, R3H or R; R : optionally hydrofluoro- or perfluoro 1-20C, preferably 1-10C linear alkyl, 2-20C, preferably 2-10C unsaturated alkyl, 3-20C, preferably 3-10C cyclic alkyl (each of the hydrocarbon radicals is optionally interrupted by >=1 heteroatoms of O, S, N or Si and optionally replaced by -OR4, -SR4, -NR4R5, -COOR4, -CONHR4, -CN, halo, 1-6C hydrofluoro- or perfluoro-alkyl or 3-8C cycloalkyl); R1R2 or 6-10C aryl; R4, R5H, OH, 1-30C (preferably 1-12C) linear, 2-30C, preferably 2-12C unsaturated (optionally perfluoro or polyfluoro)alkyl or 3-30C, preferably 3-12C aryl; R1aH, OH or R; and S1a monosaccharide or a polysaccharide containing upto 20 sugar units, preferably upto 6 sugar units of L- and/or D- pyranose and/or furanose, optionally substituted by free OH group and/or optionally protected amino group, preferably D-xylose. Provided that the S1-CH2 bond is of C-anomeric nature such as alpha or beta . #CMT#PHARMACEUTICALS : #/CMT# Preferred Composition: The composition further comprises a fatty phase such as liquid fatty phase and/or a solid fatty phase. #CMT#POLYMERS : #/CMT# Preferred Components: (II) is such as an aqueous solution, where 1 wt.% of the polymer presents a hydrating activity at least equivalent to the hydrating activity presented by an aqueous solution with 7 wt.% of glycerol, measured by Raman laser confocal microscope. (II) is nonionic, water-soluble or hydrodispersible oxyethylenated polydimethylsiloxanes, amphiphilic block copolymers containing hydrophobic polymeric block e.g. polystyrene and poly(tert-butylstyrene) and an hydrophilic nonionic polymeric block e.g. poly ethylene oxide, amphiphilic block copolymers of polyoxyethylenated poly 1-6C alkyl (meth)acrylate, polyamino acids such as polyglutamic acid, polyaspartic acid, polyleucine/polylysine, galacturonic acid derivatives such as the dextran, acrylic polymers with phosphorylcoline groups, hydrophobic polymers of acrylamido-2-methyl propane sulfonic acid and/or polyolefins. (II) is nonionic, water-soluble or hydrodispersible oxyethylenated polydimethylsiloxane (IIa) of formula (R5)3Si-O-(Si(R5)2-O)u-(Si(R5)(E)-O)v-Si(R5)3 or (R5Si)v-2[(OSiR5)u/vO-P1]v. (II) is amphiphilic block copolymers such as a diblock containing a hydrophobic polymeric block i.e. polystyrene and a hydrophilic polymeric nonionic block e.g. polyethylene oxide. The ratio of hydrophobic and hydrophilic groups in the block copolymer is 1:100 to 50:1. The amphiphilic block copolymer is polystyrene-polyoxyethylene block copolymer 1000/1000 or 1000/3000. The amphiphilic block copolymer a molecular weight of 1000-100000. The polymer is amphiphilic block copolymers of polyoxyethylenated 1-6C alkyl poly(meth)acrylate. The amphiphilic block copolymer is a diblock of formula A1-A2 in which (A1) is hydrophobic polymer block (IIb) of formula H2C=CR-CO-X and (A2) is a poly ethylene oxide, preferably polymethylethacrylate/polyoxyethylene or poly butyl metharcylate/polyoxyethylene. The ratio of A1 to A2 is 1:100 to 50:1. (II) is polyamino acids such as polyglutamic acid, polyaspartic acid, polyleucine or polylysine and the derivatives of galacturonic acid such as dextran, acrylic polymers with phosphorylcholine groups such as 2-(methacryloyloxyethyl) phosphorylcholine, 2-(methacryloyloxyethyl)phosphorylcholine/butyl methacrylate copolymer, copolymer 2-(methacryloyloxyethyl)phosphorylcholine/2-hydroxy-3-methacryloyloxypropyltrimethylammonium chloride, 2-(methacryloyloxyethyl) phosphorylcholine/sodium butyl methacrylate copolymer or 2-(methacryloyloxyethyl)phosphorylcholine/stearyl methacrylate, preferably 2-(methacryloyloxyethyl)phosphorylcholine. The acrylic polymer with phosphorylcholine group has a molecular weight of 50000-1000000, preferably 80000-800000. (II) is polyolefins with polar groups, which also comprises a polyolefinic non-polar part having >=40 carbon atoms, preferably 60-700 carbon atoms. The polyolefinic non-polar part is oligomers, polymers and/or copolymers of ethylene, propylene, 1-butylene, isobutylene, 1-pentene, 2-methyl-1- butylene, 3-methyl-1- butylene, 1-hexene, 1-heptene, 1-octene, 1-decene, 1-undecene, 1-dodecene, 1-tridecene, 1-tetradecene, 1-pentadecene, 1-hexadecene, 1-heptadecene or 1-octadecene. The polar part of the polyolefin is anionic, cationic, nonionic, zwitterionic or amphoteric. The polar part of polyolefin is polyalkylene-glycols, polyalkylene-imines, (di)carboxylic acids, their anhydrides or derivatives such as their esters, amides and/or salts. The polyolefin is polyoxyethylene, succinic anhydride, esters or amides of succinic acid or anhydride, alkaline or alkaline-earth metal salts or organic salts of the succinic acid/anhydride, or partial salts of the monoesters or monoamides of the succinic acid/anhydride. The polyolefin with polar part is a polyisobutene with optionally modified succinic termination i.e. esterified succinic termination. The polymer is hydrophobic acrylamido-2-methyl propane sulfonic acid. In formula (IIa): P1-(OC2H4)y-(OC3H6)z-OR7; R71-4C alkyl; R5monovalent hydrocarbon such as alkyl, aryl, aralkyl containing =10C, preferably methyl, phenyl or benzyl; u : 0-59; v : 1-12, preferably 5-8; E : CxH2x-(OC2H4)y-(OC3H6)z-OR6; x : 1-8, preferably 3; y : greater than 0; z : >=0, preferably 0; and R6H, 1-8C alkyl, preferably methyl, 2-8C acyl, preferably acetyl. Provided that y and z are chosen in such a way that the total molar mass of the radical E is between 200-10000 g/mol, preferably 350-3000. In formula (IIb): R : H or -CH3; X : -OR1; and R11-6C, preferably 1-4C hydrocarbon. #CMT#SPECIFIC COMPOUNDS : #/CMT# The use of 24 compounds e.g. C-beta -D-xylopyranoside-n-propane-2-one, C-alpha -D-xylopyranoside-n-propane-2-one, C-beta -D-xylopyranoside-2-hydroxy-propane (preferred), C-alpha -D-xylopyranoside-2-hydroxy-propane and/or 1-(C-beta -D-fucopyranoside)-propan-2-one, is specifically claimed as (I). #CMT#EXAMPLE : #/CMT# Typical composition comprised: 98:67:98 block copolymer of polyoxyethylene-polyoxypropylene-polyoxyethylene (1%); distilled water (to make up to 100%); and 30% C-beta -D-xylopyranoside-2-hydroxypropane solution in 60:40 water-propylene glycol mixture (2%). |
