PSEUDO PROLINE DIPEPTIDES

摘要

Disclosed is a three step process for the manufacture of pseudo proline d ipeptides of the formula (I) wherein R1 is a side chain of an alpha amino ac id , R2 is an amino protecting group and R3 and R4 are independently selecte d from hydrogen or C1-4-alkyl, R5 is hydrogen or methyl starting from an ami no acid derivative of the formula (II) wherein R1 and R2 are as above. Pseud o proline dipeptides can be used as reversible protecting groups for Ser, Th r and Cys and thus are versatile tools in peptide chemistry.