发明名称 |
COMPOSITIONS AND THERAPEUTIC METHODS OF USE |
摘要 |
A method for treating non-infectious inflammatory vulvovaginitis comprises administering to a vulvovaginal surface a pharmaceutical composition that comprises clindamycin in an amount of about 125 mg to about 400 mg per unit dose of the composition; wherein the composition is bioadhesive to the vulvovaginal surface, and upon application of the composition to the vulvovaginal surface the clindamycin is released over a period of about 3 hours to about 14 days. A related method comprises administering to a vulvovaginal surface a pharmaceutical composition comprising clindamycin or a pharmaceutically acceptable salt or ester thereof, wherein the composition has at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. A pharmaceutical composition comprises (a) clindamycin or a pharmaceutically acceptable salt or ester thereof in a clindamycin equivalent amount of about 2.5% to about 4% by weight; and (b) a phospholipid or non-ionic ester surfactant; wherein the composition is a vaginal cream having at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to a vaginal mucosal surface.
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申请公布号 |
US2008003262(A1) |
申请公布日期 |
2008.01.03 |
申请号 |
US20070769901 |
申请日期 |
2007.06.28 |
申请人 |
DRUGTECH CORPORATION |
发明人 |
LEVINSON R. SAUL;CUCA ROBERT C.;BORTZ JONATHAN |
分类号 |
A61K31/7056;A61F6/06;A61P15/02 |
主分类号 |
A61K31/7056 |
代理机构 |
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主权项 |
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地址 |
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