发明名称 |
CLICK CHEMISTRY METHOD FOR SYNTHESIZING MOLECULAR IMAGING PROBES |
摘要 |
The present disclosure provides a method for preparing a radioactive ligand or radioactive substrate having affinity for a target biomacromolecule, the method comprising: (a) reacting a first compound comprising a first functional group capable of participating in a click chemistry reaction, with a radioactive reagent under conditions sufficient to displace the leaving group with a radioactive component of the radioactive reagent to form a first radioactive compound; (b) providing a second compound comprising a second complementary functional group capable of participating in a click chemistry reaction with the first functional group; (c) reacting the first functional group of the first radioactive compound with the complementary functional group of the second compound via a click chemistry reaction to form the radioactive ligand or substrate; and (d) isolating the radioactive ligand or substrate.
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申请公布号 |
KR20080000620(A) |
申请公布日期 |
2008.01.02 |
申请号 |
KR20077024748 |
申请日期 |
2007.10.26 |
申请人 |
SIEMENS MEDICAL SOLUTIONS USA, INC. |
发明人 |
KOLB HARTMUTH C.;WALSH JOSEPH C.;CHEN KAI |
分类号 |
C07D249/04;A61K51/00;G01N33/533;G01N33/534 |
主分类号 |
C07D249/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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