发明名称 4-(N-PHENYLAMINO)-QUINAZOLINES/QUINOLINES AS TYROSINE KINASE INHIBITORS
摘要 The invention relates to the bicyclic heterocycles of the general formula (I),wherein R, R, R, Rand X are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on tyrosine kinase-mediated signal transduction. The invention also relates to the use thereof in the treatment of diseases, especially cancer diseases and of benign prostate hyperplasia (BPH), of diseases of the lung and the respiratory system, and further to the production thereof.
申请公布号 EA009300(B1) 申请公布日期 2007.12.28
申请号 EA20040001191 申请日期 2003.03.25
申请人 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG 发明人 HIMMELSBACH FRANK;JUNG BIRGIT;SOLCA FLAVIO
分类号 A61K31/517;A61K31/505;A61K31/5377;A61K31/553;A61P1/00;A61P1/04;A61P1/16;A61P11/00;A61P11/06;A61P11/08;A61P27/16;A61P35/00;A61P37/08;A61P43/00;C07D239/94;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D405/14;C07D413/12;C07D413/14;C07D491/08;C07D498/08 主分类号 A61K31/517
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