The present invention encompasses replication deficient or a replication competent adenoviral vectors which may comprise moieties covering and shielding the vector from the effects of humoral immune responses, as well as a method of constructing and using such vectors. The preferred viral constructs may incorporate the shielding moieties into the Pix coat protein of the adenovirus vectors. The invention also provides recombinant viral vectors with both shielding and specific targeting abilities. Preferably, the viral vector may comprise a nucleic acid sequence, which codes for therapeutically important genes. Methods for treating of a host with an effective amount of adenovirus vector of the present invention are also provided.
申请公布号
WO2007050128(A3)
申请公布日期
2007.12.27
申请号
WO2006US21204
申请日期
2006.05.31
申请人
VECTORLOGICS, INC.;KOVESDI, IMRE;HEDLEY, SUSAN, J.;KOROKHOV, NIKOLAY