发明名称 |
Liposome allowing liposome-entrapped substance to escape from endosome |
摘要 |
With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID NO:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions. |
申请公布号 |
US2007299244(A1) |
申请公布日期 |
2007.12.27 |
申请号 |
US20070652865 |
申请日期 |
2007.01.12 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
CHAKI SHINJI;CHAKI SHIGETADA;KOGURE KENTARO;FUTAKI SHIROH;HARASHIMA HIDEYOSHI |
分类号 |
C07K16/18;C07H21/04;C07K14/00 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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