发明名称 ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF
摘要 The application relates to compounds of the formula I: or pharmaceuticall y acceptable salts thereof, wherein: m is, from 0 to 3; q is from 0 to 3; Ar is optionally substituted aryl or optionally substituted heteroaryl; R1 and R7 each independently is halo, allkyl, haloalkyl, alkoxy, hydroxy,heteroalk yl, cyano,-S(O)-Ra,-C(=O)-NRbRC,-SO2-NRbRc,-N(Rd)-C(=O)-Re, or -C(=O)-Rf, wh ere t is from 0 to i Ra, Rb, Rc, Rd and Re each independently is hydrogen or alkyl, and Rf is hydrogen, alkyl, alkoxy or hydroxy; (II), n is from 1 to 3 ; The compounds are 5-Hydroxytryptamine 6 and 2A receptor modulators. Also p rovided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
申请公布号 CA2654822(A1) 申请公布日期 2007.12.27
申请号 CA20072654822 申请日期 2007.06.13
申请人 F. HOFFMANN-LA ROCHE AG 发明人 HARRIS, RALPH NEW, III
分类号 C07C317/32;A61K31/145;A61K31/155;A61K31/165;A61K31/17;A61K31/18;A61K31/4168;A61K31/505;A61P25/16;A61P25/18;A61P25/28;C07D233/48;C07D233/88;C07D239/14 主分类号 C07C317/32
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