摘要 |
Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a B cell, and (2) a cytotoxic agent, including a chemotherapeutic agent, radioactive isotope, cytotoxic antibody, immunoconjugate, ligand conjugate, immunosuppressant, cell growth regulator and/or inhibitor, toxin, or mixtures thereof, including agents that disrupt the cytoskeleton of B cells, particularly vinca alkaloids or colchicine. |
申请人 |
PALINGEN, INC., THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BHAT, NEELIMA M.;TENG, NELSON, N.H.;BIEBER, MARCIA M.;SANDERS, MARTIN E. |