发明名称 |
Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes |
摘要 |
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8<SUP>+</SUP> T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8<SUP>+</SUP> T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.
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申请公布号 |
US2007298046(A1) |
申请公布日期 |
2007.12.27 |
申请号 |
US20070731784 |
申请日期 |
2007.03.30 |
申请人 |
TERAJIMA MASANORI;CRUZ JOHN;ENNIS FRANCIS A |
发明人 |
TERAJIMA MASANORI;CRUZ JOHN;ENNIS FRANCIS A. |
分类号 |
A61K39/285;A61K39/00;A61K39/12;A61K39/275;A61P31/20;C07K14/07;C12Q1/70 |
主分类号 |
A61K39/285 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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