Tropical formulation comprising at least 5% of metronidazole in white petrolatum and its use in the anal and rectal region

摘要

Disclosed is a topical composition comprising at least 10-wt % metronidazole or a pharmacologically acceptable derivative thereof in a pharmacologically acceptable non-aqueous vehicle wherein the vehicle comprises at least one hydrocarbon compound. The composition may be used in the treatment of conditions of the colon, rectum, anorectum and perianal region, in particular inflammatory bowel disease and perianal Crohn's disease. The composition also relieves pain and inflammation and promotes healing of the colon, rectum, and anorectum and perianal region following surgical operations. One advantage of the composition is that topical administration of metronidazole results in a primarily local effect and thus side effects observed from systemic administration are avoided.