发明名称 |
Using electrospun polymer nanofibers in amorphous pharmaceutical compositions |
摘要 |
A process of making polymer nanofibers from either a solution or melt under electrical forces, to prepare stable, solid dispersions of amorphous drugs in polymer nanofibers is disclosed. Particularly disclosed is a process for making a stable formulation of an amphorous form of a pharmaceutically active agent, which comprises: (a) making a solution of the active agent, and a pharmaceutically acceptable polymeric carrier with a pharmaceutically acceptable solvent; and (b) electrospinning the solution of step (a) into an electrospun fiber. A pharmaceutical composition comprising an electrospun fiber of a pharmaceutically acceptable polymeric carrier homogeneously integrated with a stable amorphous form of a pharmaceutically acceptable active agent is also disclosed.
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申请公布号 |
NZ537951(A) |
申请公布日期 |
2007.12.21 |
申请号 |
NZ20030537951 |
申请日期 |
2003.08.07 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
IGNATIOUS, FRANCIS;SUN, LINGHONG |
分类号 |
A61K9/00;A61K9/20;A61K9/22;A61K9/48;A61K9/51;A61K9/52;A61K9/70;A61K31/00;A61K31/192;A61K31/353;A61K31/403;A61K31/405;A61K31/4178;A61K31/427;A61K31/4422;A61K31/47;A61K31/549;A61K31/616;A61K45/00;A61K47/10;A61K47/12;A61K47/14;A61K47/24;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61P3/06;A61P3/10;A61P5/14;A61P5/18;A61P7/02;A61P7/12;A61P9/00;A61P9/06;A61P9/08;A61P9/12;A61P11/14;A61P15/00;A61P19/00;A61P21/02;A61P25/00;A61P25/02;A61P25/08;A61P25/20;A61P25/24;A61P27/02;A61P29/00;A61P31/00;A61P31/12;A61P33/10;A61P35/00;A61P37/00;A61P37/06;A61P37/08;A61P43/00;D01F1/10;D01F6/76;(IPC1-7):A61K9/48 |
主分类号 |
A61K9/00 |
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