PURIFIED HIGH MOLECULAR WEIGHT ADIPONECTIN AND USES THEREOF

摘要

The present invention relates to high molecular weight (HMW) adiponectin, methods for its purification, and uses of the HMW adiponectin. Embodiments of the inventions includes an isolated and purified adiponectin complex composed of 18 adiponectin monomers substantially free of adiponectin trimers and hexamers; an article of manufacture comprising the HMW adiponectin complex and instructions for use of the complex in a mammalian patient; a method of preparing a purified HMW adiponectin; a method of predicting the risk of developing Type 2 diabetes by analyzing the HMW adiponectin content in a blood plasma; and a method of determining the effectiveness of a Type 2 diabetes treatment.