Tissue fixation devices including reaction causing agents

摘要

A fastener for use in fastening tissue layers in a mammalian body comprises a first member, a second member, and a connecting member fixed to each of the first and second members intermediate their ends and extending there between. One of the first and second members has a through channel along its axis arranged to be slidingly received on a tissue piercing deployment wire, and a slit extending between the first and second ends and communicating with the through channel. The connecting member includes an agent comprising a plurality of elongated fibers emanating from and carried by the connecting member that stimulates reaction of the tissue layers.