发明名称 |
GLUCURONIDATED NEBIVOLOL |
摘要 |
This invention provides glucuronidated nebivolol metabolites and pharmaceutical compositions of glucuronidated nebivolol metabolites for treatment of cardiovascular diseases. In addition, this invention also provides compositions comprising nebivolol and/or at least one glucuronidated metabolite of nebivolol and/or at least one other active compound in a pharmaceutically acceptable carrier. This invention also provides methods of treating and/or preventing vascular diseases, by administering at least one glucuronidated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease. Also, this invention is directed to the treatment and/or prevention of migraine headaches administering at least one glucuronidated metabolite of nebivolol. This invention may also be used in conjunction with or as a single treatment of metabolic syndrome disorders. |
申请公布号 |
EP1866323(A2) |
申请公布日期 |
2007.12.19 |
申请号 |
EP20060719897 |
申请日期 |
2006.01.30 |
申请人 |
MYLAN LABORATORIES, INC |
发明人 |
O'DONNELL, JOHN, P.;OWENS, WALTER;DUNCAN, JOSEPH;SHAW, ANDREW |
分类号 |
C07H7/033;A61K31/7012;A61K31/7048;A61P9/00;A61P9/08 |
主分类号 |
C07H7/033 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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