Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites

摘要

Disclosed is a pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and, as active ingredient an acrolyl distamycin derivative of formula (I) wherein R1 is a bromine or chlorine atom, R2 is distamycin or a distamycin-like framework; or a pharmaceutically acceptable salt thereof; and an antimicrotubule agent optionally together with an antimetabolite.