PROCESS FOR PRODUCING POLYMER MICELLE ENCLOSING HYDROPHOBIC DRUG

摘要

A method of causing a polymer micelle to enclose a hydrophobic drug. The method comprises the steps of (1-a) dissolving or dispersing a hydrophobic drug in a lower alcohol; (1-b) providing an aqueous medium containing a polymer micelle consisting of a block copolymer with hydrophilic region and hydrophobic region; and (1-c) mixing the lower alcohol solution or dispersion having the hydrophobic drug dissolved or dispersed therein with the aqueous medium containing the polymer micelle to thereby cause the polymer micelle to enclose the hydrophobic drug. The solubility in water of the hydrophobic drug is lower than the solubility in the lower alcohol.