发明名称 |
Artificial carrier particles and method for preparation thereof |
摘要 |
<p>An artificial carrier particle comprising an anionic polymer and a synthetic polyamino acid having at least one carboxylic group and at least one amino group in its side chain, the complex being insolubilized by an aldehyde crosslinking agent. The artificial carrier particle is useful in immunoassays, in particular, particle immunoassays. The artificial carrier particles are obtained by preparing an aqueous solution containing an anionic polymer and a synthetic polyamino acid comprising at least one free carboxyl group and at least one free amino group in its side chain, adjusting the pH of the solution to 3.5 to 9.5 at room temperature or at progressively increasing temperature under stirring to form a solution of particles of a desired particle size, and insolubilizing the particles by an aldehyde crosslinking agent.</p> |
申请公布号 |
EP0363921(B1) |
申请公布日期 |
1996.09.25 |
申请号 |
EP19890118879 |
申请日期 |
1989.10.11 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
HIRAI, TAKENORI;IHARA, HIROTAKA;HIRAYAMA, CHUICHI;FUZITA, HARUO;SAISHO, MUNEHIRO |
分类号 |
G01N33/544;A61K9/16;C08B37/00;C08F8/28;G01N33/543;G01N33/548;(IPC1-7):C08F8/28;G01N33/53 |
主分类号 |
G01N33/544 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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